In vitro analysis of SiO2 - MgO -P2O5 - CaO bioactive material for bone regeneration applications

In vivo bonding with the surrounding tissue is the most efficient property possessed by the biomaterials by accumulating Hydroxyapatite (HA) on their surface. The present study elucidates the synthesis of biomaterials by quick alkali mediated sol–gel process. Further, X-Ray Diffraction, Fourier Transform Infra-red spectroscopy (to check formation of HA), Brunauer–Emmett–Teller (BET), Degradation w.r.t pH and cell viability by MTT assay using MG-63cell line techniques have been employed. Results show that synthesized sample possess the growth of HA within the 24 hr when dipped in body like fluid. Optimum degradation rate is an important aspect for the biomaterials and sample has shown good degradation rate w.r.t. formation of HA. In vitro biological assay performed shows the non-toxic behavior of sample with the viability of cells in the culture media hinting proliferation of cells. Therefore, sample can be nominated as possible candidate for orthopedic applications.