T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins.

Stephanie Schlichtner,Inna M Yasinska,Gurprit S Lall,Steffen M Berger,Sabrina Ruggiero,Dietmar Cholewa,Nijas Aliu,Bernhard F Gibbs,Elizaveta Fasler-Kan,Vadim V Sumbayev

Journal for immunotherapy of cancer（2023）

引用 9|浏览11

暂无评分

摘要

Our results underline a crucial role of galectin-9 in anticancer immune evasion. As such, galectin-9 and regulatory pathways controlling its production should be considered as key targets for immunotherapy in a large number of cancers.

查看译文

关键词

Immune Evation,Receptors, Immunologic,T-Lymphocytes,Tumor Microenvironment

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要