KO t Bu-Promoted, Three-Component Domino Reaction of Arenes(indoles/phenols), C 60 , and (Per/poly)fluoroarenes: Achieving Direct C-C Cross-Coupling of Fullerene with (Per/poly)fluoroarenes.

A KOBu-promoted, three-component cross-coupling of arenes(indoles/phenols), C, and (per/poly)fluoroarenes has been established for the one-pot efficient synthesis of various 1,4-arene-bridged bis(polyfluoroaryl)-functionalized [60]fullerenes. This developed reaction system demonstrates good functional group compatibilities with broad substrate scope, which exhibits high regio- and chemoselectivities. Further control experiment succeeded in providing a one-pot protocol for the synthesis of various 1,2--(per/poly)fluoroarene-substituted 1,2-(3-indole)(hydro)fullerenes.