Click approach for synthesis of 3,4-dihydro-2(1H) quinolinone, coumarin moored 1,2,3-triazoles as inhibitor of mycobacteria tuberculosis H37RV, their antioxidant, cytotoxicity and in-silico studies
Journal of Molecular Structure(2022)
Abstract
•Simple synthetic procedures were employed to synthesize new triazole bridged bi-heterocycles.•Synthesized scaffolds were assessed for their in vitro antitubercular, antioxidant, cytotoxic and superoxide dismutase enzyme activities.•The scaffolds were proven to be potential anti-TB agents.•Molecular docking studies with DprE1 enzyme shown similar interaction of compounds as that of FDO ligand.•The scaffolds may be considered for in vivo use as lead drug.
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Key words
Click chemistry,1,2,3-Triazole,3,4-Dihydro-2(1H)-quinolinone,Coumarin,Mycobacterium tuberculosis H37Rv
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