Elucidating the anti-oxidant and anti-inflammatory potentials of Triticum aestivum against ulcerative colitis: An in vivo and in silico study

•Ulcerative colitis an irremediable disease because of its relapse and recurrence despite intake of conventional medicine.•Triticum Aestivum, a common wheat possess a strong anti-inflammatory and antioxidants properties due to the presence of over 100compounds docked, with scores ranging from 1.227 (1-Nonanol) to −8.298. (Quercetin).•Bioactive ingredients of triticum aestivum such as Quercetin, Protocatechuic acid 4-glucosideis, Tricin showed aggreater inhibition against Expression COX-2 in inflaammationg during healing of acetic induced ulcerative colitis.•Stachyose, allantoin and tetrakis(2-benzimidazolylmethyl)-2‑hydroxy-1,3-diamino propane scored highest against IL-6 and are component of triticum aestivum, reducing the inflammation during experimental ulcerative colitis.