Ameliorative effects of Danshensu from the functional food Salvia miltiorrhiza against arsenic trioxide-induced cardiac toxicity in vivo and in vitro: Involvement of inhibiting the AKT/IKK/NF-κB signaling pathway

Yakun Yang,Jiaying Qi, Hua Wang,Yang Zhao,Yongchao Wu,Zhonglin Wu,Jing Shi,Weizhong Qu,Li Chu

Journal of Functional Foods（2022）

引用 2|浏览12

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摘要

•Cardiotoxicity of arsenic trioxide limits its clinical utility.•Danshensu has anti-oxidant, anti-inflammatory, and anti-apoptotic activities.•Danshensu shows the protective effects on arsenic trioxide-induced cardiotoxicity.•Protective mechanisms are related to the inhibition of AKT/IKK/NF-κB pathway.

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关键词

Danshensu,Arsenic trioxide,Cardiotoxicity,Oxidative stress,AKT/IKK/NF-κB pathway,Apoptosis

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