Stigmasterol inhibits cancer stem cell activity in endometrial cancer by repressing IGF1R/mTOR/AKT pathway

Wen-Ling Wang,Shih-Ming Chen,Yueh-Chun Lee,Wen-Wei Chang

Journal of Functional Foods（2022）

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摘要

•Stigmasterol induces G1 cell cycle arrest in endometrial cancer (EC) cell.•Stigmasterol inhibits epithelial-mesenchymal-transition in EC cells.•Stigmasterol reduces the expression of cancer stemness genes in EC cells.•Stigmasterol suppresses the activation of IGF1R/AKT/mTOR pathway in EC cells.

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关键词

Stigmasterol,Phytosterol,Endometrial cancer,IGF1R,AKT,mTOR

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