A20, as a downstream factor of Nrf2, is involved in the anti-neuroinflammatory and antidepressant-like effects of luteolin

Journal of Functional Foods(2022)

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摘要
•Luteolin exerted anti-neuroinflammatory and antidepressant-like effects.•Luteolin upregulated the expression of A20 and Nrf2.•Upregulation of A20 and Nrf2 was involved in the inhibitory effects of luteolin on neuroinflammation.•A20, as a downstream factor of Nrf2, was involved in the inhibitory effects of luteolin on activation of microglia.
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关键词
Neuroinflammation,Depression,Luteolin,Microglia
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