A20, as a downstream factor of Nrf2, is involved in the anti-neuroinflammatory and antidepressant-like effects of luteolin

•Luteolin exerted anti-neuroinflammatory and antidepressant-like effects.•Luteolin upregulated the expression of A20 and Nrf2.•Upregulation of A20 and Nrf2 was involved in the inhibitory effects of luteolin on neuroinflammation.•A20, as a downstream factor of Nrf2, was involved in the inhibitory effects of luteolin on activation of microglia.