Differential Uridyl-diphosphate-Glucuronosyl Transferase 1A enzymatic arsenal explains the specific cytotoxicity of resveratrol towards tumor colorectal cells

•Resveratrol differential effect in healthy and cancer cells is poorly understood.•UGT1A8/1A10 enzymes conjugate resveratrol into non-toxic metabolites in healthy intestinal cells.•UGT1Agene downregulation results in resveratrol toxicity in CRC and healthy intestine cells.•UGT1Agene expression is downregulated in patient’s colorectal cancer tissues and metastases.•Resveratrol leads to nucleotide imbalance uncoupling cell growth and proliferation in CRC cells.