Association of Meal Timing of Energy, Macronutrients and Foods with Hypercholesterolaemia in the US Adults.

Few studies examined the association of energy, macronutrients and food consumption at dinner v. breakfast with hypercholesterolaemia. A total of 27 911 participants from the National Health and Nutrition Examination Survey (2003-2016) were included in the cross-sectional study. Energy, macronutrients and food consumption at breakfast, dinner and the difference at dinner v. breakfast (Delta ratio) were calculated. Multiple logistic regression models and substitution effects of foods at dinner with breakfast were also performed. After adjustment for potential covariates, compared with the lowest quintile, participants in the highest quintile of Delta ratio in terms of energy had a higher risk of prevalent hypercholesterolaemia (OR Delta ratio of energy 1 center dot 16, 95 % CI (1 center dot 01, 1 center dot 33)) mainly due to Delta ratio of low-quality carbohydrates and plant protein (OR Delta ratio of low-quality carbohydrates 1 center dot 19; 95 % CI (1 center dot 05, 1 center dot 35)); OR Delta ratio of plant protein 1 center dot 13; 95 % CI (1 center dot 01, 1 center dot 28)). Delta Added sugars and Delta nuts were associated with hypercholesterolaemia (OR Delta added sugars 1 center dot 01; 95 % CI (1 center dot 00, 1 center dot 02)); OR Delta nuts 1 center dot 08; 95 % CI (1 center dot 01, 1 center dot 16)). Furthermore, the substitution of added sugars, nuts and processed meat at dinner with breakfast could reduce the OR of hypercholesterolaemia. This study indicated that among US adults, overconsumption of energy, macronutrients including low-quality carbohydrates and plant protein at dinner than breakfast was significantly associated with a higher risk of prevalent hypercholesterolaemia. The replacing of added sugar, nuts and processed meat at dinner with breakfast reduced the risk of prevalent hypercholesterolaemia. This study emphasised the importance of meal timing in the prevention of hypercholesterolaemia.