Exosome-derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase-3-dependent cleavage.

Lifeng Ding,Qiming Zheng,Yudong Lin,Ruyue Wang, Huan Wang,Wenqin Luo,Zeyi Lu,Haiyun Xie,Liangliang Ren,Haohua Lu,Chenhao Yu, Jixuan Zhang,Danyang Shen,Sheng Cheng,Liqun Xia,Gonghui Li,Dingwei Xue

Clinical and translational medicine（2023）

引用 7|浏览18

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摘要

In general, our study demonstrated that circTFDP2 promoted PCa cell progression through the PARP1/DNA damage axis, which may be a promising therapeutic target for PCa.

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关键词

DNA damage,PARP1,circTFDP2,prostate cancer

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