Identification of Genes Involved in EGF-induced Apoptosis Using CRISPR/Cas9 Knockout Screening: Implications for Novel Therapeutic Targets in EGFR-Overexpressing Cancers.

Jae Sik Kim,Joo Ho Lee,Sang-Rok Jeon,Yongsub Kim,Seung Hyuck Jeon,Hong-Gyun Wu

Cancer research and treatment（2023）

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摘要

The CRISPR-based knockout screen revealed 266 genes possibly responsible for EGF-induced apoptosis. DUSP1 might be a critical component of EGF-induced apoptosis and a novel target for EGFR-overexpressing cancers.

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关键词

Apoptosis,CRISPR screen,DUSP1,Epidermal Growth Factor

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