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Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation.

Biying Zhang, Jiao Li,Qingling Hua,Haihong Wang,Guojie Xu,Jiayuan Chen, Ying Zhu,Ruiqi Li,Qing Liang,Lanqing Wang,Min Jin, Jing Tang,Zhenyu Lin,Lei Zhao,Dejun Zhang,Dandan Yu,Jinghua Ren,Tao Zhang

Journal for immunotherapy of cancer（2023）

Cited 3|Views28
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Abstract
Overall, our study unveils a novel regulatory mechanism of MHC-I on tumor cell surfaces by CEMIP-mediated internalization and degradation. Furthermore, targeting CEMIP provides an effective strategy for colorectal cancer immunotherapy.
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CD8-positive T-lymphocytes,antigen presentation,tumor escape
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