The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice.

Xiaoling Cao,Vi Nguyen,Joseph Tsai,Chao Gao,Yan Tian,Yuping Zhang,Wayne Carver,Hippokratis Kiaris,Taixing Cui,Wenbin Tan

bioRxiv : the preprint server for biology（2023）

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摘要

Our data demonstrated that the Spike protein could induce long-term transcriptional suppression of mitochondria metabolic genes and cause cardiac fibrosis and myocardial contractile impairment, providing mechanistic insights to PACS-related cardiomyopathy.

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