Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations.

Smruthy Sivakumar,Dexter X Jin, Ruchita Rathod,Jeffrey Ross,Lewis C Cantley,Maurizio Scaltriti,Jessica W Chen,Katherine E Hutchinson,Timothy R Wilson,Ethan S Sokol,Neil Vasan

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

Our pan-tumor study provides biological insights into the genetic heterogeneity and tissue specificities of multi-PIK3CA mutations, with potential clinical utility to guide PI3K inhibition strategies.

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