Base Editing of Human Hematopoietic Stem Cells.

Jing Zeng,Gabriele Casirati,My Anh Nguyen,Pietro Genovese,Daniel E Bauer

Methods in molecular biology (Clifton, N.J.)（2023）

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摘要

Base editing by nucleotide deaminases linked to programmable DNA-binding proteins represents a promising approach to remedy blood disorders. Here we describe the ex vivo base editing of human CD34+ hematopoietic stem and progenitor cells (HSPCs) by electroporation of base editor mRNA or protein.

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关键词

Base editing,CD34+ hematopoietic stem and progenitor cells,Electroporation

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