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Wnt Signaling Regulates MFSD2A-dependent Drug Delivery through Endothelial Transcytosis in Glioma.

Yuan Xie,Liqun He,Yanyu Zhang, Hua Huang,Fan Yang,Min Chao,Haiyan Cao,Jianhao Wang,Yaling Li,Lingxue Zhang,Lele Xin, Bing Xiao, Xinxin Shi, Xue Zhang,Jiefu Tang,Lene Uhrbom,Anna Dimberg,Liang Wang,Lei Zhang

Neuro-oncology（2023）

Cited 3|Views28
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Abstract
These results demonstrated that Wnt signaling regulates MFSD2A-dependent TMZ delivery through a caveolae-mediated EC transcytosis pathway. Our findings identify Wnt signaling as a promising therapeutic target to improve drug delivery for GBM treatment.
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Key words
Wnt signaling,blood-brain barrier,drug delivery,endothelial cell,glioblastoma
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