MD2 Inhibits Choroidal Neovascularization via Antagonizing TLR4/MD2 Mediated Signaling Pathway.

Qi Wu,Zhang Chen, Chenxin Wu,Lingxi Zhang, Yuyang Wu,Xiyuan Liu,Yi Wang,Zongduan Zhang

Current eye research（2023）

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摘要

Inhibiting MD2 with L2H17 significantly reduced CNV, suppressed inflammation, and oxidative stress by antagonizing TLR4/MD2 pathway in an MD2-dependent manner. MD2 may be a potential therapeutic target and L2H17 may offer an alternative treatment strategy for nAMD.

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关键词

Age-related macular degeneration,chalcone analogs,inflammation,myeloid differentiation protein 2,oxidative stress

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