Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?

Liver cancer（2022）

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摘要

SULF2 derived from CAFs modulates glypican-3/β-catenin signalling but also the HCC immune TME, associated with tumour progression and therapy resistance via activation of the TAK1/IKKβ/NF-κB pathway. It is an attractive target for combination therapies for patients with HCC.

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关键词

Biomarkers,Glypican-3,Hepatocellular carcinoma,Inflammation,Metabolic disease,Molecular targets,NASH,Spheroids,Sulfatase-2,Tumour microenvironment

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