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Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?

Marco Y W Zaki,Sari F Alhasan,Ruchi Shukla,Misti McCain,Maja Laszczewska,Daniel Geh,Gillian L Patman,Despina Televantou,Anna Whitehead,João P Maurício,Ben Barksby,Lucy M Gee,Hannah L Paish,Jack Leslie,Ramy Younes,Alastair D Burt,Lee A Borthwick,Huw Thomas,Gary S Beale,Olivier Govaere,Daniela Sia,Quentin M Anstee,Dina Tiniakos,Fiona Oakley,Helen L Reeves

Liver cancer（2022）

Cited 4|Views44
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Abstract
SULF2 derived from CAFs modulates glypican-3/β-catenin signalling but also the HCC immune TME, associated with tumour progression and therapy resistance via activation of the TAK1/IKKβ/NF-κB pathway. It is an attractive target for combination therapies for patients with HCC.
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Key words
Biomarkers,Glypican-3,Hepatocellular carcinoma,Inflammation,Metabolic disease,Molecular targets,NASH,Spheroids,Sulfatase-2,Tumour microenvironment
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