pH-responsive and targeted delivery of chrysin via folic acid-functionalized mesoporous silica nanocarrier for breast cancer therapy

Noyel Ghosh,Mousumi Kundu,Sumit Ghosh,Abhishek Kumar Das,Samhita De,Joydeep Das,Parames C Sil

International Journal of Pharmaceutics（2023）

引用 7|浏览5

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摘要

•A smart, pH-sensitive,FA fabricated and PAA coated mSiO2 nanocarrier has been formulated.•Anticancer efficacy of chrysin has been upgraded through its folate receptor oriented delivery.•Probable detailed anticancer mechanism of Chr-mSiO2@PAA/FA has been studied in vitro.•In vivo pro-apoptotic nature of Chr-mSiO2@PAA/FA has been solicited.•Chr-mSiO2@PAA/FA has found to be highly biocompatible with no significant systemic toxicity.

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关键词

Cancer,Chrysin,Mesoporous silica nanoparticle,pH-dependent drug release,Receptor-mediated targeted drug delivery

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