Differential Sodium Current Remodelling Identifies Distinct Cellular Proarrhythmic Mechanisms in Paroxysmal vs Persistent Atrial Fibrillation.

Simona Casini,Gerard A Marchal,Makiri Kawasaki,Benedetta Fabrizi,Robin Wesselink,Fransisca A Nariswari,Jolien Neefs,Nicoline W E van den Berg,Antoine H G Driessen,Joris R de Groot,Arie O Verkerk,Carol Ann Remme

The Canadian journal of cardiology（2023）

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摘要

Our findings demonstrate differences in (late) I remodeling in LAA-CMs from patients with paroxysmal vs persistent AF, indicating distinct cellular proarrhythmic mechanisms in different AF forms. These observations are of particular relevance when considering potential pharmacologic approaches targeting (late) I in AF.

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atrial fibrillation,sodium

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