Detangling the structural neural correlates associated with resting versus dynamic phantom limb pain intensity using a voxel-based morphometry analysis.

Our results suggest an essential role of the non-affected mid-anterior insula as an integrating hub of PLP perception and its severity and thus being a critical network for resting PLP intensity. On the other hand, the sensorimotor gray matter volume seems to be critical to ultimately influence the likelihood of dynamic PLP intensity changes related to a neuromodulatory treatment aimed at sensorimotor cortex modulation. These results point out to the importance in differentiating resting vs. dynamic structural brain correlates associated with PLP control.