HIV-1C in-House RNA-Based Genotyping Assay for Detection of Drug Resistance Mutations in Samples with Low-Level Viral Loads.

Ontlametse T Bareng,Wonderful T Choga,Segomotso T Maphorisa,Sekgabo Seselamarumo,Kaelo K Seatla,Patrick T Mokgethi,Dorcas Maruapula,Mompati L Mogwele,Doreen Ditshwanelo,Natasha O Moraka,Irene Gobe,Modisa S Motswaledi,Joseph M Makhema,Rosemary Musonda,Roger Shapiro, Max Essex,Vlad Novitsky,Sikhulile Moyo,Simani Gaseitsiwe

Infection and drug resistance（2022）

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摘要

The in-house HIV genotyping assay successfully genotyped 72% of LLV samples and was able to detect 17% of DRM amongst them. Our results highlight the possibility and clinical significance of genotyping HIV among individuals with LLV.

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关键词

HIV-1C drug resistance testing,in-house genotyping,low-level viremia,samples

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