STATUS OF THE CELLULAR IMMUNITY IN CLEAN-UP WORKERS OF THE CHORNOBYL ACCIDENT AND PATIENTS WITH CANCER OF THE MOUTH CAVITY, ORAL AND LARYNGEAL PART OF THE PHARYNX.

L M Zvarych, D A Bazyka,I M Ilienko,N A Golyarnik, O V Liaskivska, O A Belayev, V V Panchenko, M O Vorobyov

Problemy radiatsiinoi medytsyny ta radiobiolohii（2022）

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Abstract

The obtained results show the unidirectionality of changes in cellular immunity in the participants of the liquidation of the consequences of the accident at the Chornobyl nuclear power plant and patients with the investigated oncological pathology, which indicates the formation of persistent violations of antitumor protection in the participants of the liquidation of the consequences of the accident as the basis of oncogenesis. Determining changes in the number of lymphocytes, monocytes, granulocytes, CD4+ T-lymphocytes, CD4+ CD8+ immature T-lymphocytes, the immunoregulatory ratio CD4+ / CD8+, CD3+TCRαβ+ T-lymphocytes and CD3+ 16+ 56+ CTL can have an additional effect on the effectiveness antitumor protection and the probability of oncogenesis risk in immunocompromised individuals.

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Key words

Chornobyl,clean-up workers of the Chornobyl accident,immune system,ionizing radiation,neoplasms of the oral cavity,oral and laryngeal parts of the pharynx

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