NLRP3 inflammasome inhibitor MCC950 reduces cerebral ischemia/reperfusion induced neuronal ferroptosis

Xiang Wu,Bo Wang,Yunfei Zhou,Zhongbo Yang,Liangchao Jiang,Zhiyan Kou,Jiaxi Li,Xudong Ma,Jinning Song

Neuroscience Letters（2023）

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摘要

•NLRP3 inflammasome is activated during cerebral ischemia–reperfusion (I/R).•MCC950 reduces neuronal pyroptosis induced by cerebral I/R.•MCC950 attenuates neuronal ferroptosis induced by cerebral I/R.•MCC950 attenuates ferroptosis may depend on reduced ROS accumulation.

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关键词

NLRP3 inflammasome,MCC950,Cerebral ischemia–reperfusion,Ferroptosis,Pyroptosis

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