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Obesity-induced memory deficits in female rats are oestrous cycle-dependent and linked to impaired brain kynurenine pathway metabolism.

Carla Elena Mezo-González, Juan Antonio García Santillán,Luis A Reyes-Castro,Mathilde Gourdel,Mikaël Croyal,Francisco Bolaños-Jiménez

Neuroendocrinology（2022）

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Abstract
The results presented here indicate that the deleterious effects of obesity on learning are closely related to the oestrous cycle and associated with an impairment of the kynurenine pathway of tryptophan metabolism.
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Key words
Kynurenine pathway,Learning,Obesity,Oestrous cycle,Sex differences,Tryptophan
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