Changing roles of CD3 + CD8 low T cells in combating HIV-1 infection.

Xin Zhang,Xiuwen Wang,Ling Qin,Xiaofan Lu,Zhiying Liu,Zhen Li,Lin Yuan,Rui Wang,Junyan Jin,Zhenglai Ma,Hao Wu,Yonghong Zhang, Tong Zhang, Bin Su

Chinese medical journal（2023）

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摘要

Our findings suggest that CD3 + CD8 low T cells play an anti-HIV role in the first month of infection due to their abundance but induce a weak HIV-1-specific immune response. Subsequently, CD3 + CD8 low T-cell number decreased gradually as infection persisted, and their anti-HIV functions were inferior to those of CD3 + CD8 high T cells.

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