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CIDE-stepping E3s

Gary Tin,Georg E. Winter

Nature chemical biology（2022）

Cited 0|Views7
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Abstract
Small-molecule-mediated targeted protein degradation (TPD) relies on the recruitment of a target protein of interest to an E3 ligase. A new study indicates how direct target recruitment to the 26S proteasome can bypass this requirement.
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Key words
Chemical tools,Proteins,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry
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