Granulocytic myeloid-derived suppressor cells to prevent and treat murine immune-mediated bone marrow failure

Xingmin Feng,Jisoo Kim,Gladys Gonzalez-Matias,Nidhi Aggarwal, Ash Lee Manley,Zhijie Wu,Sabrina Solorzano,Sai Batchu,Shouguo Gao,Jichun Chen,Neal S. Young

Blood Advances（2023）

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摘要

•Granulocytic MDSCs attenuate immune marrow failure in a minor histocompatibility antigen mismatched murine model.•T-cell inhibition and hematopoietic cell preservation are key mechanisms of granulocytic MDSC therapy.

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