Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis.

Guangya Wang,W K Jacky Lam,Lowell Ling,Mary-Jane L Ma, Saravanan Ramakrishnan, Don C T Chan,Wing-Shan Lee,Suk Hang Cheng,Rebecca W Y Chan,Stephanie C Y Yu, Irene O L Tse,Wai Tat Wong,Peiyong Jiang,Rossa W K Chiu,K C Allen Chan,Y M Dennis Lo

Clinical chemistry（2023）

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摘要

The use of fragmentomic features could facilitate the differentiation of underlying contaminating microbes from true pathogens in sepsis. This work demonstrates the potential usefulness of microbial cfDNA fragmentomics in metagenomics analysis.

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infectious organisms,microbiology,molecular diagnostics

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