Antigen Discovery for Next-Generation Pertussis Vaccines Using Immunoproteomics and Transposon-Directed Insertion Sequencing.

Kelsey A Gregg,Yihui Wang,Jason Warfel, Elizabeth Schoenfeld,Ewa Jankowska,John F Cipollo,Matthew Mayho,Christine Boinett, Deepika Prasad,Timothy J Brickman,Sandra K Armstrong,Julian Parkhill,Ricardo Da Silva Antunes,Alessandro Sette,James F Papin,Roman Wolf,Tod J Merkel

The Journal of infectious diseases（2023）

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摘要

The B. pertussis antigens identified as immunogenic, essential for persistence in the airway, and membrane-localized warrant further investigation for inclusion in vaccines designed to reduce or prevent carriage of bacteria in the airway of vaccinated individuals.

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关键词

Bordetella pertussis ,TraDIS,antigen,baboon,immunization,immunoproteomics,vaccine,whooping cough

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