Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners.

Simin Zhao,Baisong Zheng,Liuli Wang,Wenzhe Cui,Chunlai Jiang,Zhuo Li,Wenying Gao,Wenyan Zhang

Chinese medical journal（2022）

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摘要

USP3 restricts HIV-1 viral infections by increasing the expression of the antiviral factor A3G. Therefore, USP3 may be an important target for drug development and serve as a novel therapeutic strategy against viral infections.

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关键词

APOBEC3G,Ubiquitin-specific protease 3,Deubiquitination,Human immunodeficiency virus-1 Vif,Human immunodeficiency virus,Deubiquitinase

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