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Real-world outcomes from use of CDK4/6 inhibitors in the management of advanced/metastatic breast cancer in Asia.

Jia Li Low,Elaine Lim,Lavina Bharwani,Andrea Wong,Karmen Wong,Samuel Ow,Siew Eng Lim,Matilda Lee,Joan Choo,Joline Lim,Gloria Chan,Robert John Walsh,Vaishnavi Muthu,Natalie Ngoi,Wanqin Chong,Sing Huang Tan,Soo Chin Lee

Therapeutic advances in medical oncology（2022）

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Abstract
Our study indicates CDK4/6i is effective and safe. Age ⩾ 70, distant metastases to liver, peritoneal or brain were negative prognostic factors. Age ⩾ 70 was associated with significantly increased requirement for dose modification; however, this did not impact survival outcomes. These findings provide reassurance that survival outcomes are not adversely affected in elderly patients when DD/DR is indicated.
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Key words
Asia,CDK4/6 inhibitors,advanced/metastatic breast cancer,real world
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