Humoral immune response following a third SARS-CoV-2 mRNA vaccine dose in solid organ transplant recipients compared with matched controls.

Daniel Balsby,Anna Christine Nilsson,Inge Petersen,Susan O Lindvig,Jesper Rømhild Davidsen,Rozeta Abazi,Mikael K Poulsen,Inge K Holden,Ulrik S Justesen,Claus Bistrup,Isik Somuncu Johansen

Frontiers in immunology（2022）

Cited 5|Views8

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Abstract

A third COVID-19 vaccine dose resulted in a significant increase in humoral immunogenicity in SOT recipients and maintained high response rate in controls. Furthermore, SOT recipients were less likely to produce antibodies with overall lower antibody concentrations and humoral immunity was highly influenced by the presence of liver disease and diabetes. The prevalence of breakthrough infections was similar in the two groups.

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Key words

COVID-19 vaccine,Solid organ transplant,comorbidities,humoral response,third dose

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