Development and validation of a cuproptosis-related lncRNA model correlated to the cancer-associated fibroblasts enable the prediction prognosis of patients with osteosarcoma

•Cuproptosis-related lncRNAs prognostic model demonstrated exceptional prognostic efficacy for osteosarcoma patients.•The biological function of identified differentially expressed genes with cuproptosis-related lncRNAs’ risk model was closely related to the PI3K-Akt pathway.•Cuproptosis-related lncRNAs were associated with osteosarcoma CAFs.•Erlotinib, MP470, and WH-4-023 might potentially effectively target the PI3K-Akt pathway drugs for OS.