HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.

Haowei Wang,Yujia Chen,Qinzi Yuan,Lixia Chen,Peiling Dai,Xuenong Li

Frontiers in oncology（2022）

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摘要

Our study demonstrates that HRK is lowly expressed in colorectal cancer tissues. And for the first time, HRK was shown to promote apoptosis and inhibit proliferation of colorectal cancer cells by inhibiting PI3K/AKT/mTOR signaling pathway. HRK represents a potential target for the treatment of CRC.

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关键词

CRC,HRK,apoptosis,mTOR,proliferation,rapamycin

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