Regulatory mechanism of icariin in cardiovascular and neurological diseases

Yuling Wang,Chang Shang,Yang Zhang,Laiyun Xin, Linke Jiao,Mi Xiang,Zihuan Shen,Chen Chen, Fan Ding,Yingdong Lu,Xiangning Cui

Biomedicine & Pharmacotherapy（2023）

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摘要

Cardiovascular diseases (CVDs) and neurological diseases are widespread diseases with substantial rates of morbidity and mortality around the world. For the past few years, the preventive effects of Chinese herbal medicine on CVDs and neurological diseases have attracted a great deal of attention. Icariin (ICA), the main constituent of Epimedii Herba, is a flavonoid. It has been shown to provide neuroprotection, anti-tumor, anti-osteoporosis, and cardiovascular protection. The endothelial protection, anti-inflammatory, hypolipidemic, antioxidative stress, and anti-apoptosis properties of ICA can help stop the progression of CVDs and neurological diseases. Therefore, our review summarized the known mechanisms and related studies of ICA in the prevention and treatment of cardio-cerebrovascular diseases (CCVDs), to better understand its therapeutic potential.

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关键词

CVD,YYH,ICA,HPLC,ICA II,ICT,IRS II,IHD,PAD,HUVECs,PI3K,Akt,MAPK,ERK,NO,eNOS,ADMA,LDL,HDL,VLDLs,TG,TFE,ICAM-1,HCD,SR-BI,CD36,NAFLD,LPS,TLR4,IKK,c-JNK,NF- κB,IL-1,TNF-Α α,IFN-γ,IL-6,OS,ROS/RNS,XOs,SODs,CATs,GSH-Px,Trx,MMPs,VSMCs,MIRI,I/R,HF,mES,ISO,tPA,CNS,AD,TGF- β 1,MSCs,MCAO,ER,Aβ,BACE-1,BCCAO,GSK3β,ROS,NDs,,BDNF,HPA axis,CRF,CORT,FKBP5,SGK1

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