Molecular Imaging of Matrix Metalloproteinase-2 in Atherosclerosis Using a Smart Multifunctional PET/MRI Nanoparticle.

Yingfeng Tu,Xiaowei Ma,Hao Chen,Yuhua Fan,Lei Jiang,Ruiping Zhang,Zhen Cheng

International journal of nanomedicine（2022）

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摘要

Using a combination of innovative imaging modalities, in this study, we demonstrate the feasibility of applying the novel smart MMP2cNPs as a PET/MR hybrid imaging contrast agent for detection of MMP-2 in atherosclerotic plaque in vivo.

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关键词

atherosclerosis,macrophage,magnetic resonance imaging,matrix metalloproteinase-2,nanoparticles,positron emission tomography

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