A metabolomic-based biomarker discovery study for predicting phototherapy duration for neonatal hyperbilirubinemia.

Danying Zhu,Mingjie Wang,Zhongxiao Zhang, Minghua Liu,Yiwen Liu,Weiling Wu,Dian Lu, Xiaoyun Wu,Wei Wu,Xingyun Wang

Translational pediatrics（2022）

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Abstract

Our research found that the differential metabolites were associated with the duration of neonatal jaundice and that glycerophospholipid metabolism might have played a role in this biological process. Moreover, metabolites such as PE (22:1(13Z)/15:0), PC (18:1(9Z)/18:1(9Z)), PS (22:0/15:0), 5,6-dihydrouridine, and PE (MonoMe(11,3)/MonoMe(13,5)) could be used as predictors for phototherapy duration in neonatal hyperbilirubinemia and assist with decision-making.

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Key words

Neonatal hyperbilirubinemia,bilirubin encephalopathy,green light,metabolites,predict diagnosis

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