Blockade of mineralocorticoid receptor by low-dose spironolactone rescues hypothalamic-ovarian dysfunction in PCOS experimental rat model

Stephanie E. Areleogbe,Mmenyene U. Peter,Adesola A. Oniyide,Christopher O. Akintayo,Adedamola A. Fafure,Mosunmola B. Oyeleke,Isaac O. Ajadi,Oluwatobi A. Amusa,Aturamu Ayodeji,Kehinde S. Olaniyi

Endocrine and Metabolic Science（2022）

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摘要

•PCOS is characterized with hypothalamic-ovarian dysfunction (HOD).•HOD is associated with decreased hypothalamic kisspeptin.•MR blockade by low-dose spironolactone (LDS) alleviates HOD.•LDS improves hypothalamic kisspeptin level.

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关键词

Hypothalamus,Inflammation,Kisspeptin,Mineralocorticoids,Ovary

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