Biotinylated Pt(IV) prodrugs with elevated lipophilicity and cytotoxicity

Daniil V Spektor,Alexander Erofeev,Petr Gorelkin,Dmitry Skvortsov,Alexander Trigub,Alina Markova,Nikitina Vita,Nikolay Ul’yanovskii,Alexander Shtil,Alevtina Sergeevna Semkina,Kseniya Yu Vlasova,Nikolai Zyk,Alexander Majouga,Elena K. Beloglazkina,Olga O. Krasnovskaya, Lilia Vasil'eva

Dalton Transactions（2023）

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摘要

A design of Pt(IV) prodrugs with tumor cell targeting moieties leading to increased selectivity is of interest. Herein, we designed a novel Pt(IV) prodrugs with COX-inhibitor naproxen, long-chain hydrophobic stearic...

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