Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Roman Thomas and colleagues report exome sequencing of 29 small-cell lung cancers (SCLCs), 2 SCLC genomes and transcriptomes of 15 SCLCs. They identify recurrent mutations in the CREBBP , EP300 and MLL genes encoding histone modifiers. They identify mutations in SLIT2 and EPHA7 , which have a role in axon guidance and cell migration, and focal amplifications of FGFR1 .