MiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2.

Xiaowen Cao,Fangsu Xue, Haoyu Chen,Lu Shen,Xiaosa Yuan,Yunchi Yu, Ying Zong,Lou Zhong, Fang Huang

Annals of translational medicine(2022)

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Abstract
was lowly expressed in lung cancer tissue. overexpression inhibited the proliferation and metastasis of lung cancer cells. was highly expressed in lung cancer tissue and promoted the proliferation and metastasis of lung cancer cells. targeted and inhibited , thereby reducing the proliferation and metastasis of LUAD cells. LUAD patients with low expression had a better prognosis, and the expression level of was correlated with the clinical characteristics of lung cancer patients.
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Key words
Lung adenocarcinoma (LUAD),metastasis,miR-202-3p,proliferation,ribonucleotide reductase regulatory subunit M2 (RRM2)
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