CCNE1 and survival of patients with tubo‐ovarian high‐grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study

Eun‐Young Kang,Ashley Weir,Nicola S. Meagher,Kyo Farrington,Gregg S. Nelson,Prafull Ghatage,Cheng‐Han Lee,Marjorie J. Riggan,Adelyn Bolithon,Gordana Popovic,Betty Leung,Katrina Tang,Neil Lambie,Joshua Millstein,Jennifer Alsop,Michael S. Anglesio,Beyhan Ataseven,Ellen Barlow,Matthias W. Beckmann,Jessica Berger,Christiani Bisinotto,Hans Bösmüller,Jessica Boros,Alison H. Brand,Angela Brooks‐Wilson, Sara Y. Brucker,Michael E. Carney,Yovanni Casablanca,Alicia Cazorla‐Jiménez,Paul A. Cohen,Thomas P. Conrads,Linda S. Cook,Penny Coulson,Madeleine Courtney‐Brooks,Daniel W. Cramer,Philip Crowe,Julie M. Cunningham,Cezary Cybulski,Kathleen M. Darcy,Mona A. El‐Bahrawy,Esther Elishaev,Ramona Erber,Rhonda Farrell,Sian Fereday,Anna Fischer,María J. García,Simon A. Gayther,Aleksandra Gentry‐Maharaj,C. Blake Gilks,Marcel Grube,Paul R. Harnett,Shariska Petersen Harrington,Philipp Harter,Arndt Hartmann,Jonathan L. Hecht,Sebastian Heikaus,Alexander Hein,Florian Heitz,Joy Hendley,Brenda Y. Hernandez,Susanna Hernando Polo,Sabine Heublein,Akira Hirasawa,Estrid Høgdall,Claus K. Høgdall,Hugo M. Horlings,David G. Huntsman,Tomasz Huzarski,Andrea Jewell,Mercedes Jimenez‐Linan,Michael E. Jones,Scott H. Kaufmann,Catherine J. Kennedy,Dineo Khabele,Felix K. F. Kommoss,Roy F. P. M. Kruitwagen,Diether Lambrechts,Nhu D. Le,Marcin Lener,Jenny Lester,Yee Leung,Anna Linder,Liselore Loverix,Jan Lubiński,Rashna Madan,G. Larry Maxwell,Francesmary Modugno,Susan L. Neuhausen,Alexander Olawaiye,Siel Olbrecht,Sandra Orsulic,José Palacios,Celeste Leigh Pearce,Malcolm C. Pike,Carmel M. Quinn,Ganendra Raj Mohan,Cristina Rodríguez‐Antona,Matthias Ruebner,Andy Ryan,Stuart G. Salfinger,Naoko Sasamoto,Joellen M. Schildkraut,Minouk J. Schoemaker,Mitul Shah,Raghwa Sharma,Yurii B. Shvetsov,Naveena Singh,Gabe S. Sonke, Linda Steele,Colin J. R. Stewart,Karin Sundfeldt,Anthony J. Swerdlow,Aline Talhouk,Adeline Tan,Sarah E. Taylor,Kathryn L. Terry,Aleksandra Tołoczko,Nadia Traficante,Koen K. Van de Vijver,Maaike A. van der Aa,Toon Van Gorp,Els Van Nieuwenhuysen,Lilian van‐Wagensveld,Ignace Vergote,Robert A. Vierkant,Chen Wang,Lynne R. Wilkens,Stacey J. Winham,Anna H. Wu,Javier Benitez,Andrew Berchuck,Francisco J. Candido dos Reis,Anna DeFazio,Peter A. Fasching,Ellen L. Goode,Marc T. Goodman,Jacek Gronwald,Beth Y. Karlan,Stefan Kommoss,Usha Menon,Hans‐Peter Sinn,Annette Staebler,James D. Brenton,David D. Bowtell,Paul D. P. Pharoah,Susan J. Ramus,Martin Köbel

Cancer（2022）

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摘要

This study provides large-scale validation that CCNE1 high-level amplification is associated with shorter survival, supporting its utility as a prognostic biomarker in HGSC.

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关键词

CCNE1 amplification,cyclin E1 expression,high-grade serous carcinoma,ovarian cancer,prognosis

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