Intrahepatic quantification of HBV antigens in chronic hepatitis B reveals heterogeneity and treatment-mediated reductions in HBV core-positive cells.
JHEP reports : innovation in hepatology(2023)
Abstract
HBV infects liver hepatocyte cells, and its genome can exist in two forms that express different sets of viral proteins: a circular genome called cccDNA that can express all viral proteins, including the HBV core and HBsAg proteins, or a linear fragment that inserts into the host genome typically to express HBsAg, but not HBV core. We used new techniques to determine the percentage of hepatocytes expressing the HBV core and HBsAg proteins in a large set of liver biopsies. We find that abundance and patterns of expression differ across patient groups and even within a single liver and that NUC treatment greatly reduces the number of core-expressing hepatocytes.
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Key words
ADV, adefovir,ALT, alanine aminotransferase,Biomarkers,CHB, chronic hepatitis B,CNN, convolutional neural network,HBV,HBV core,HBV core, hepatitis B core antigen,HBV, Hepatitis B Virus,HBcrAg, hepatitis B core-related antigen,HBeAg,HBeAg, Hepatitis B e antigen,HBsAg,HBsAg, Hepatitis B surface antigen,HCC, hepatocellular carcinoma,IF, immunofluorescence,NUC,NUC, nucleo(t)side,Na+K+-ATPase, sodium–potassium ATPase,QC, quality control,TDF, tenofovir disoproxil fumarate,cccDNA, covalently closed circular DNA,dslDNA, double-stranded linear DNA
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