Facile Synthesis of Diaryl Sulfones through Arylsulfonylation of Arynes and Thiosulfonates
Synthesis（2022）
Abstract
A mild and transition-metal free arylsulfonylation reaction of arynes has been developed. Arynes generated in situ from 2-(trimethylsilyl)aryl triflates undergo nucleophilic addition with thiosulfonates to produce diaryl sulfones in 41-99% yields. The reaction can be easily scaled up to grams and high yield can be maintained. Finally, the mechanism experiments showed that acetonitrile acted as proton source.
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Key words
arynes,thiosulfones,aryl sulfones,coupling,aryl-sulfur bonds
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