CCR5 contributes to adverse outcomes during malaria in pregnancy

Yusmaris Cariaco,Andrea Tatiana Durán-Rodriguez,Marcos Paulo Oliveira Almeida,Neide Maria Silva

Cytokine（2023）

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摘要

•Malaria in late gestation induced placental upregulation of CCR5.•CCR5 deficiency prevented poor pregnancy outcomes caused by malaria.•CCR5-/- placentas had higher area for feto-maternal exchange and reduced TNF levels.•CCR5 deficiency led to smaller NAG activity in the placenta during infection.

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关键词

CCR5,Malaria,Pregnancy,TNF,Fetal growth restriction,Preterm birth

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