Amber Light Control of Peptide Secondary Structure by a Perfluoroaromatic Azobenzene Photoswitch.
Chembiochem : a European journal of chemical biology(2023)
Abstract
The incorporation of photoswitches into the molecular structure of peptides and proteins enables their dynamic photocontrol in complex biological systems. Here, a perfluorinated azobenzene derivative triggered by amber light was site-specifically conjugated to cysteines in a helical peptide by perfluoroarylation chemistry. In response to the photoisomerization (trans→cis) of the conjugated azobenzene with amber light, the secondary structure of the peptide was modulated from a disorganized into an amphiphilic helical structure.
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Key words
amber light,decafluoroazobezene,peptide stapling,perfluoroarylation,photocontrol
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