Cystathionine γ-lyase self-inactivates by generating supersulfides

〈Introduction〉Cystathionine γ-lyase (CSE) is an enzyme responsible for the biosynthesis of cysteine from cystathionine. It also has the β-lyase activity toward cystine to generate cysteine hydropersulfide (Cys-SSH). Notably, the chemical reactivity of Cys-SSH is thought to be involved in the catalytic activity of proteins via protein polysulfidation. In the present study, we investigated Cys-SSH could regulate CSE enzyme activity through its polysulfidation.