Ultrastructural Axon-Myelin Unit Alterations in Multiple Sclerosis Correlate with Inflammation.

Aletta M R van den Bosch,Sophie Hümmert,Anna Steyer,Torben Ruhwedel,Jörg Hamann,Joost Smolders,Klaus-Armin Nave,Christine Stadelmann,Maarten H P Kole,Wiebke Möbius,Inge Huitinga

Annals of neurology（2023）

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摘要

These data suggest that in MS NAWM myelin detachment and uncompact myelin wrapping occurs, potassium channels are unmasked at the nodes of Ranvier, and axonal energy demand is increased, or mitochondrial transport is stagnated, accompanied by increased presence of activated and phagocytic microglia and T cells. These subclinical alterations to the axon-myelin unit in MS NAWM may contribute to disease progression. ANN NEUROL 2023;93:856-870.

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关键词

axon–myelin unit alterations,<scp>multiple sclerosis</scp>,inflammation

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